Patients were divided into four cohorts and administered iontophoretic EGP-437 at either 9mA-min or 14mA-min on Day 0, Day 1 and Day 2 or Day 0, Day 1 and Day 4, with potential for an additional treatment at Day 7 in all cohorts. A positive response, determined by reduction in Anterior Chamber Cell count (ACC) at day 28, was observed in the majority of patients in cohort 4. Subjects receiving the 14 mA-min dose at days 0, 1 and 4 demonstrated the most significant ACC improvement, with 40% of subjects in this cohort achieving an ACC count of 0 at day 14 which increased to 88% on day 28. Additionally, all subjects administered the iontophoretic treatment experienced reduction in pain at all time points with 90% having no pain as early as day 1 and increasing to 100% on day 14 again in this 14 mA-min cohort. Patients tolerated the procedure well and liked the idea of not using daily eyedrops. No steroid related increase in intraocular pressure was reported. no dataThe effective management of pain and inflammation is key to optimizing post-surgical outcomes for cataract surgery patients. The results of the 14mA-min dose administered on days 0, 1 and 4 compares favorably to historical control data from current standard of care on Days 7, 14 and 28 for subjects with an ACC count of zero and with little to no pain at all time points for our product, said Randall Olson M.D., Scientific Advisory Board Member of EyeGate. no dataWe believe these data warrant further assessment of iontophoretic EGP-437 through the addition of three new cohorts to the current trial to evaluate additional doses and dosing regimens and further improve upon these encouraging results. We expect top-line data from the additional cohorts in the fourth quarter of 2016, and remain on track to initiate a randomized, placebo-controlled trial of iontophoretic EGP-437 in cataract surgery patients by the end of the year. With approximately 3 million cataract surgeries performed in the U.S.
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